Hex may mean:

• Hex (board game).
• Hex (Discworld), a fictional computer from Terry Pratchett's Discworld novels.
• Hex (Doctor Who), a character in the Big Finish Productions audio plays based on the television series Doctor Who.
• Hex (TV Series).
• Hex (album), an album by the band Bark Psychosis.
• Hex (band), a heavy metal band.
• Hex (book), set in New York City.
• Hex (film), a 1973 film
• A Greek root word denoting "six" as in "hexagon", a six-sided geometric figure.
• Abbreviation of hexadecimal, a base-16 number system often used when doing low-level work on computers (e.g., assembly or machine code programming).
• Hex River, South Africa.
• A curse or magical spell.
• pow-wow (folk magic), the Pennsylvania German magical system of "hex work".
• The name of a trilogy of sci-fi books by Rhiannon Lassiter.
• A madhouse ride at Alton Towers theme park in Staffordshire, England.
• Hex (VJ group), A British-based multimedia group active in the 1990s, which later became Hexstatic.
• Jonah Hex, a DC Comics character.