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An analgesic (colloquially known as a painkiller) is any member of the diverse group of drugs used to relieve pain and to achieve analgesia. This derives from Greek an-, "without", and -algia, "pain". Analgesic drugs act in various ways on the peripheral and central nervous system; they include paracetamol (acetaminophen), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, narcotic drugs such as morphine, synthetic drugs with narcotic properties such as tramadol, and various others. Some other classes of drugs not normally considered analgesics are used to treat neuropathic pain syndromes; these include tricyclic antidepressants and anticonvulsants.
The major classes
Paracetamol and NSAIDs
The exact mechanism of action of paracetamol is uncertain, but it appears to be acting centrally. Aspirin and the NSAIDs inhibit cyclooxygenase, leading to a decrease in prostaglandin production; this improves pain and also inflammation (in contrast to paracetamol and the opioids).Paracetamol has few side effects, but dosing is limited by possible hepatotoxicity (potential for liver damage). NSAIDs may predispose to peptic ulcers, renal failure, allergic reactions, and hearing loss. They may also increase the risk of hemorrhage by affecting platelet function. The use of certain NSAIDs in children under 16 suffering from viral illness may contribute to Reye's syndrome.
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Painkiller :: Computer and Video
i dont wanna take any painkiller so im gonna sleep now.goodnite everyone!
nilepattz (Nil Enkavi) Mon, 21 Dec 2009 21:34:08 -0000
i dont wanna take any painkiller so im gonna sleep now.goodnite everyone!
is waiting for my 3rd rolfing appt. The last one cut my painkiller intake in half. Very exciting!
eyemgodmama (eyemgodmama) Mon, 21 Dec 2009 21:30:10 -0000
is waiting for my 3rd rolfing appt. The last one cut my painkiller intake in half. Very exciting!
@jobybutler ... shouldn't that be 'Look in my eyes Maury, you're killing me, killing me?' Okay yes that was bad... painkiller humor FTW!
Livewire6277 (Elise) Mon, 21 Dec 2009 21:22:47 -0000
@jobybutler ... shouldn't that be 'Look in my eyes Maury, you're killing me, killing me?' Okay yes that was bad... painkiller humor FTW!
The PainKiller~truly beautiful with honey & toasted coconut on rim. Limit 2-f'real Cheers http://twitpic.com/ujev0
pillpushera (amy ) Mon, 21 Dec 2009 20:12:49 -0000
The PainKiller~truly beautiful with honey & toasted coconut on rim. Limit 2-f'real Cheers http://twitpic.com/ujev0
RT @adamandeve: Ladies, got cramps? Relieve menstrual cramps with masturbation! Orgasms act as a natural painkiller. #sextip
STD_Test_Expres (STD_Test_Express) Mon, 21 Dec 2009 19:17:00 -0000
RT @adamandeve: Ladies, got cramps? Relieve menstrual cramps with masturbation! Orgasms act as a natural painkiller. #sextip
Coming soon, in Hollywood: Painkiller Instinct.
fbattaglin (Fabiano Battaglin) Mon, 21 Dec 2009 19:12:35 -0000
Coming soon, in Hollywood: Painkiller Instinct.
3D Gamers - Information, news, screenshots, and downloads.
Meta Description: [ Painkiller downloads, Painkiller demos, Painkiller maps, Painkiller patches, Painkiller screenshots, Painkiller images, Painkiller pics, Painkiller wallpaper, Painkiller trailers ]
DreamCatcher Games - Publisher. Includes game features and system requirements.
Meta Description: [ THe Adventure Company is a publisher of high quality adventure games for your pc, mac PlayStation and PlayStation 2. ]
GameAmp - Includes screen shots, patches, weapon guides, cheat codes and a forum.
Meta Description: [ Painkiller at GameAmp features cheats, cheat codes, walk throughs, demos, patches, walk throughs, hints and screenshots for all your addictive PK needs. ]
GameGuru Mania - Interview with Simon Vivien, Brand Manager at DreamCatcher Games. Includes screen shots.
Meta Description: [ The definitive source for PC and video games, PS2, Xbox, GameCube, PS3, Xbox360, PSP and GBA news, cheats, codes, guides, movies, announcements, ship dates, rankings, sales figures, and more ]
Painkiller - Official site. Offers game overview, screen shots, multimedia downloads, news and discussion forums.
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